Robaxin (methocarbamol injection, USP) Injectable, a carbamate spinoff of guaifenesin, is a central anxious technique (CNS) depressant with sedative and musculoskeletal relaxant homes. It is a sterile, pyrogen-no cost resolution supposed for intramuscular or intravenous administration.
Clinical pharmacology
The mechanism of motion of methocarbamol in human beings has not been proven, but might be due to standard CNS depression. It has no direct motion on the contractile mechanism of striated muscle, the motor stop plate or the nerve fiber.
Indications and usage
The injectable kind of methocarbamol is indicated as an adjunct to relaxation, physical remedy, and other actions for the relief of pain involved with acute, distressing musculoskeletal problems. The mode of action of this pill has not been clearly discovered, but may perhaps be associated to its sedative attributes. Methocarbamol does not directly unwind tense skeletal muscle tissue in man.
Dosage and administration
For Intravenous and Intramuscular Use Only. Complete adult dosage should not exceed thirty mL (3 vials) a day for much more than three consecutive days except in the treatment method of tetanus. If the affliction persists, a like class may perhaps be repeated just after a pill-totally free interval of forty eight several hours. Dosage and frequency of injection should really be based on the severity of the ailment staying addressed and therapeutic response mentioned.
For the reduction of indicators of reasonable degree, one particular dose of 1 gram (one particular 10 mL vial) might be adequate. Ordinarily this injection require not be repeated, as the administration of the oral sort will usually sustain the relief initiated by the injection. For the severest circumstances or in postoperative situations in which oral administration is not feasible, supplemental doses of 1 gram may perhaps be repeated every single 8 hours up to a greatest of 3 g/day for no much more than three consecutive days.
Directions for Intravenous Use
Robaxin Injectable may well be administered undiluted specifically into the vein at a highest pace of a few mL for each moment. It may also be extra to an intravenous drip of Sodium Chloride Injection (Sterile Isotonic Sodium Chloride Option for Parenteral Use) or five percent Dextrose Injection (Sterile five percent Dextrose Remedy) a single vial offered as a solitary dose really should not be diluted to a lot more than 250 mL for I.V. infusion. Just after MIXING WITH I.V. INFUSION FLUIDS, DO NOT REFRIGERATE. Treatment must be exercised to keep away from vascular extravasation of this hypertonic alternative, which may well outcome in thrombophlebitis. It is preferable that the client be in a recumbent position throughout and for at least 10 to 15 minutes subsequent the injection.
Directions for Intramuscular Use
When the intramuscular route is indicated, not more than five mL (an individual-fifty percent vial) should be injected into just about every gluteal region. The injections could be repeated at eight hour intervals, if necessary. When satisfactory reduction of signs or symptoms is achieved, it can typically be preserved with tablets.
Contraindications
Robaxin Injectable should really not be administered to patients with recognized or suspected renal pathology. This caution is needed simply because of the existence of polyethylene glycol 300 in the vehicle.
A considerably much larger quantity of polyethylene glycol 300 than is present in advisable doses of Robaxin Injectable is acknowledged to have greater pre-present acidosis and urea retention in individuals with renal impairment. While the sum current in this planning is well inside the limits of security, caution dictates this contraindication.
Robaxin Injectable is contraindicated in individuals hypersensitive to methocarbamol or to any of the injection parts.
Overdosage
Restricted details is available on the acute toxicity of methocarbamol. Overdose of methocarbamol is usually in conjunction with alcohol or other CNS depressants and contains the following signs: nausea, drowsiness, blurred eyesight, hypotension, seizures, and coma. In post-advertising experience fatalities have been reported with an overdose of methocarbamol by yourself or in the existence of other CNS depressants, alcohol or psychotropic medication.